At The Skin Nurse in Teddington, I specialise in helping women over 30 achieve healthy, naturally radiant skin.
Polynucleotide treatments are one of our most exciting innovations, a regenerative therapy designed to repair, restore and rejuvenate the skin from the inside out.
What are Polynucleotides?
Polynucleotides (often known by brands such as Nucleofill or Plinest) are purified DNA fragments derived from salmon or trout, completely sterile and biocompatible with human tissue. When injected into the skin, they signal your own cells to regenerate, hydrate and repair.
Think of them as a cellular reboot: they help fibroblasts produce collagen and elastin, calm inflammation, and improve tissue oxygenation. The result? Skin that looks fresher, firmer and more luminous, not overfilled or frozen.
How do Polynucleotides work?
Over time, our skin’s cellular turnover slows, collagen depletes and oxidative stress increases. Polynucleotides tackle all three.
Once injected, they:
- Stimulate fibroblast activity to rebuild collagen and elastin
- Hydrate deeply by increasing water retention in the extracellular matrix
- Reduce inflammation and oxidative damage
- Promote tissue healing and resilience
This makes them particularly powerful for thinner or crepey skin, under-eye hollows, and post-inflammatory changes.
Treatment areas
- Under-eye rejuvenation (one of the most popular uses)
- Face and neck
- Décolletage
- Scalp and hairline (for hair rejuvenation)
Each treatment is quick, around 30 minutes, with minimal downtime. You may experience tiny bumps or redness for 24–48 hours, and of course as a needle is involved bruising is possible, especially when treating under they eyes, I can use a cannula here which reduces the chances.
Treatment course & results
For best results, I usually recommend a course of three sessions, spaced 3–4 weeks apart. Improvements appear gradually as new collagen and elastin form over 6–12 weeks.
Results typically last around six months, after which a maintenance session keeps skin looking its best.
Profhilo vs. Polynucleotides — what’s the difference?
| Feature | Profhilo | Polynucleotides |
|---|---|---|
| Main ingredient | Pure hyaluronic acid | DNA fragments (nucleotides) |
| Main action | Deep hydration & collagen stimulation | Cellular repair & regeneration |
| Ideal for | Dehydration, dullness, mild laxity | Fine lines, under-eyes, inflammation, skin healing |
| Course | 2 sessions, 4 weeks apart | 3–4 sessions, 3–4 weeks apart |
| Works well with | Botox, fillers, skin boosters | Microneedling, LED, peels |
They’re different tools, both beautiful on their own, or combined for next-level rejuvenation.
Investment
- Single session — £350
- Course of three — £900
(Courses are spaced three to four weeks apart)
👉 View the full Price List ›
Can I combine Polynucleotides with other treatments?
Absolutely, I often combine them with microneedling and/or LED light therapy for enhanced collagen stimulation and healing. This is a excellent Regenerative Duo treatment which blends both approaches for visibly smoother, firmer skin.
👉 Learn more about Microneedling & LED treatments ›
Who are they for?
Polynucleotides are ideal for clients aged 30+ who want to:
- Tackle early lines or skin laxity
- Brighten dull, tired or uneven skin
- Improve crepey texture under the eyes or on the neck
- Support post-inflammatory repair or sun damage
- Strengthen skin before or after other aesthetic treatments
Safety and science
The polynucleotide products used at The Skin Nurse are CE-marked and non-human origin, making them safe, traceable and effective.
All treatments are carried out by Louise Walsh, Registered Nurse Prescriber, in a clinical, CQC-aligned environment.
Frequently Asked Questions
Are polynucleotides the same as fillers?
No. Fillers replace lost volume; polynucleotides work on a cellular level to regenerate and strengthen the skin.
How soon will I see results?
Most clients notice a smoother, fresher complexion after their second session, with continued improvement for several months.
Can I have this around the eyes?
Yes, polynucleotides are exceptional for delicate under-eye skin that’s too thin for filler.
Are there any side effects?
Mild redness or small bumps can occur for 24–48 hours. Bruising is possible. Serious reactions are extremely rare when performed by a medical professional.
Ready to repair, restore and glow?
If your skin feels tired, thin or lacklustre or you’ve started noticing those early under-eye lines — now’s the time to begin your regenerative journey.
Book Your Polynucleotide Consultation ›
The Skin Nurse — ethical aesthetic treatments for confident, natural beauty across Teddington, Twickenham and Richmond.